Topic
Evidence Grading
Evidence Grading is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
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Metabolic Health
Seed Oils and Inflammation, Metabolism, and Cancer: Endpoint-by-Endpoint Grades
Biomarker metas largely spare dietary n-6 as pro-inflammatory; lipids often improve with n-6; T2D observational signals sometimes favor LA; cancer data inconsistent—fry mutagens are a separate issue.
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Nutrition
Seed Oil Contested Claims: Adjudicating Inflammation, Toxicity, and Heart Disease
Grade claims separately: industrial fryer abuse (fair concern), essential LA as poison (false), AHA replacement (guideline-supported), Cochrane hard-outcome caution (real). Avoid faction epistemology.
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Men's Health
Red Light Therapy for Men: Hair, Sports Recovery, Skin—and Hormone Hype Grades
Best-supported male use cases: AGA hair LLLT (Grade A), sports muscle preconditioning (Grade B), cosmetic skin (smaller male fractions). Testosterone and fertility miracle claims: Grade D.
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Expert Dossiers
Paul Saladino’s Seed-Oil Opposition: Evidence Adjudication
Separate industrial frying abuse and UPF matrices from refined oil used in home cooking. AHA/Cochrane-class evidence does not support categorical seed-oil poison claims.
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Expert Dossiers
Paul Saladino Public Debates and Media Reception: How to Read the Coverage
Profiles, podcasts, and diet wars amplify charisma. Separate documented protocol claims from culture-war framing and secondary misquotes.
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Expert Dossiers
Paul Saladino vs Mainstream Nutrition Science: Where Claims Align and Clash
Shared ground: cut UPFs, prioritize protein quality. Clash: plant exclusion, seed-oil absolutism, raw dairy, and universal optimality versus DASH/Mediterranean evidence.
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Hormones & Genes
MTHFR Variant Frequency by Population: Why “Positive” Is Common
C677T and A1298C alleles are common globally with ancestry differences. Common ≠ rare disease. Frequency should lower panic, not sell protocols.
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Hormones & Genes
MTHFR in Functional Medicine vs ACMG Framing: Two Different Languages
ACMG cautions against routine MTHFR SNP testing for common indications. Functional-medicine marketing often expands SNPs into multi-system narratives. Know which frame you are in.
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Environmental Health
Urinary Mycotoxin Tests: Evidence Grade for Indoor Mold Claims
Commercial urine mycotoxin panels are poorly validated for diagnosing building-related illness. Diet, lab variability, and weak clinical utility undermine cleanse-driving results.
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Light & Recovery
Finnish Sauna vs Infrared: Physics, Evidence Mapping, and Modality Conflation
Finnish dry ~80–100°C carries hard-outcome cohorts. Consumer IR ~45–60°C must not inherit KIHD hazard ratios. Waon is a clinical far-IR protocol, not spa marketing.
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Nutrition
Seasonal Eating Romanticism vs Evidence: Critiques That Keep the Good Parts
Keep produce variety, cooking, and low UPF. Drop ancestral purity, anti-global efficiency myths, and health claims that outrun data.
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Nutrition
Polyphenols and Harvest Timing: Ripeness Chemistry Without Clinical Overclaim
Anthocyanins and phenolics track ripeness, UV, water stress, and cultivar. Peak density ≠ proven independent disease prevention. Patterns beat polyphenol calendars.
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Expert Dossiers
Paul Saladino Human Evidence: Surveys, Trials Gap, and What Lennerz Actually Is
Human evidence for carnivore/animal-based is mostly self-selected surveys and anecdotes—not hard-outcome RCTs. Never call Lennerz a Harvard clinical trial.
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Expert Dossiers
Paul Saladino Commercial Conflicts: Heart & Soil, Products, and Disclosure Rules
Organ capsules, protocol product bridges, luxury retail collabs, and raw-dairy culture create COI priors. Disclose always; COI does not auto-falsify every claim.
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Expert Dossiers
Paul Saladino: From Strict Carnivore to Animal-Based — Why Version-Stamping Matters
Saladino's public arc moved vegan → carnivore → fruit-and-honey animal-based after self-reported ketosis side effects. Date-stamp every claim.
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Nutrition
Seasonal Vitamins and Minerals in Produce: Real Swings, Modest Clinical Stakes
Composition varies by season, cultivar, maturity, and storage—e.g., spinach vitamin C more than 2× across seasons in Phillips 2018. Total produce frequency still dominates health.
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Women's Health
Menstrual Cycle Training: Why Rigid Follicular/Luteal Periodization Is Premature
Umbrella review: premature to claim short-term ovarian hormone swings appreciably change strength performance or RT adaptations. Prefer symptom autoregulation.
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Nutrition
Local Eating Health Claims: What Is Proven vs Postal-Code Therapy
No RCTs show “buying local” per se prevents CVD/cancer. Benefits run through diet quality, produce intake, and behavior—not zip codes. Grade local seal as clinical therapy: D.
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Women's Health
Jack Kruse Women’s Health Angles: Cycles, FHA Risk, and Two-Leptin Problem
Female early signs may differ, but aggressive low-energy stacks risk functional hypothalamic amenorrhea. Low leptin in undernutrition is the opposite of obesity leptin resistance.
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Expert Dossiers
Jack Kruse Water Structure Claims: Queer Water and EZ Myths
Bulk water anomalies are textbook chemistry. Pollack-style exclusion-zone health theories are contested. Clinical structured-water cures are unsupported.
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