Topic
Mthfr
Mthfr is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
-
Hormones & Genes
MTHFR: What to Do and What to Skip (2026)
Do food folate and pregnancy-era folic acid evidence; don't routine SNP panic or detox methylation stacks.
-
Hormones & Genes
When MTHFR-Related Testing Means Phenotype or Rare Disease
Common SNPs are not IEM workups. Measure homocysteine and standard labs for phenotype; reserve rare severe MTHFR deficiency testing for true inborn-error presentations—not wellness panels.
-
Hormones & Genes
MTHFR Is Not an Actionable Thrombophilia or CVD Indication
Unlike factor V Leiden, common MTHFR SNPs do not change anticoagulation or CVD prevention. Homocysteine-lowering RCTs failed hard outcomes; RPL management is not genotype-driven.
-
Women's Health
MTHFR, Pregnancy, and Lactation: Folic Acid Priority
NTD prevention runs on folic acid dose and timing—not boutique genotypes. CDC/USPSTF set the standard; lactation nutrition still prioritizes maternal diet quality over SNP kits.
-
Nutrition
Actionable One-Carbon Nutrition Without MTHFR Genotype
You do not need a SNP to take folic acid for pregnancy, fix B12 deficiency, or eat leafy greens. Grade A actions are phenotype- and life-stage-driven.
-
Hormones & Genes
ACMG MTHFR Guideline: Do Not Routinely Genotype
ACMG 2013 (with later addendum pathway) finds minimal clinical utility for common MTHFR SNPs—do not order for thrombophilia, RPL, or cascade relatives.
-
Hormones & Genes
MTHFR Variant Frequency by Population: Why “Positive” Is Common
C677T and A1298C alleles are common globally with ancestry differences. Common ≠ rare disease. Frequency should lower panic, not sell protocols.
-
Metabolic Health
Homocysteine Treatment Thresholds in Clinical Context (MTHFR Angle)
Homocysteine is a lab analyte with context—not a wellness score. Treat deficiencies and indicated elevations; do not chase perfection because of an MTHFR SNP.
-
Hormones & Genes
MTHFR in Functional Medicine vs ACMG Framing: Two Different Languages
ACMG cautions against routine MTHFR SNP testing for common indications. Functional-medicine marketing often expands SNPs into multi-system narratives. Know which frame you are in.
-
Hormones & Genes
MTHFR Myths, Debunked (2026)
Common MTHFR claims ranked by evidence harm—folate, folic acid, SNPs, and when genetics actually change care.
-
Hormones & Genes
Severe MTHFR Deficiency vs Common C677T/A1298C SNPs
Two-bucket genetics: rare biallelic disease versus population polymorphisms.
-
Nutrition
One-Carbon Nutrition Actions Graded by Evidence
What to do for folate status without an MTHFR test—A through D action list.
-
Hormones & Genes
MTHFR, Thrombophilia, CVD, and Recurrent Pregnancy Loss Myths
Why common MTHFR SNPs are not managed like factor V Leiden—and what HOPE-2 means for hearts.
-
Women's Health
MTHFR, Pregnancy, and Lactation: Evidence-Based Guidance
Periconception folic acid rules, what changes in pregnancy, and what does not change with SNPs.
-
Women's Health
MTHFR Variants and Neural Tube Defect Risk: Epidemiology
OR ~1.6 for maternal 677TT, folate-modifiable risk, and why intake outranks genotype.
-
Men's Health
MTHFR in Men: Fertility Claims and Cardiovascular Axes
What male-factor fertility blogs get wrong—and what CVD trials actually measured.
-
Hormones & Genes
Direct-to-Consumer MTHFR Testing: Counseling and Misinterpretation Risks
How raw SNP reports become medical stories—and how to counsel without ACMG violations.
-
Hormones & Genes
MTHFR C677T and A1298C: Enzyme Activity vs Clinical Meaning
Teaching residual-activity percentages, thermolabile biology, and why common SNPs are not rare disease.
-
Nutrition
Methylation Supplement Industry Claims: An Evidence Audit
Pathway diagrams versus outcome trials—what methylation stacks can and cannot claim.
-
Women's Health
Folic Acid for Neural Tube Defect Prevention: Guideline Doses
USPSTF Grade A 400–800 mcg, CDC 400 mcg and 4 mg recurrence rules, and why form matters.
Frequently asked