Topic
Mthfr
Mthfr is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
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Nutrition
Excess Folate and B12 Masking: Risks Beyond MTHFR Marketing
Why high-dose folate without B12 checks can hide hematologic clues while nerves worsen.
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Metabolic Health
Folate Cycle and One-Carbon Metabolism Explained
How MTHFR, methionine synthase, B12, and SAM connect—without methylation-product theater.
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Hormones & Genes
MTHFR and Nutrition: What to Actually Do (2026)
ACMG-aligned MTHFR actions: skip routine SNP testing hype, use folic acid for NTD prevention, food folate, B12 when deficient, homocysteine context, avoid megadose theater.
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Hormones & Genes
Riboflavin, MTHFR C677T, and Blood Pressure: The Targeted Trial Signal
1.6 mg riboflavin helped 677TT hypertensives in trials—not a cure for “MTHFR disease.”
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Hormones & Genes
Homocysteine, MTHFR, and When the Lab Phenotype Matters
Homocysteine is the actionable phenotype more often than a C677T sticker.
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Hormones & Genes
Folate vs Folic Acid and MTHFR: What the Evidence Actually Supports
Folic acid prevents neural-tube defects. Methylfolate marketing is not a free rewrite of CDC guidance.
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Hormones & Genes
MTHFR Gene Variants: What Actually Matters Clinically
C677T and A1298C explained with ACMG non-utility, CDC folic acid facts, and riboflavin research graded honestly.
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Hormones & Genes
ACMG MTHFR Testing Guidance: Why Routine SNP Orders Are Discouraged
ACMG: do not order MTHFR polymorphism testing for thrombophilia or recurrent pregnancy loss. Fortification-era evidence dismantled the old causal chain.
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