Topic
Inflammation
Inflammation is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
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Metabolic Health
Seed Oils and Inflammation, Metabolism, and Cancer: Endpoint-by-Endpoint Grades
Biomarker metas largely spare dietary n-6 as pro-inflammatory; lipids often improve with n-6; T2D observational signals sometimes favor LA; cancer data inconsistent—fry mutagens are a separate issue.
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Nutrition
Seed Oil Contested Claims: Adjudicating Inflammation, Toxicity, and Heart Disease
Grade claims separately: industrial fryer abuse (fair concern), essential LA as poison (false), AHA replacement (guideline-supported), Cochrane hard-outcome caution (real). Avoid faction epistemology.
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Metabolic Health
Sauna, Inflammation, Metabolism, and Brain Outcomes: Beyond Heart Death Endpoints
Habitual Finnish sauna associates with lower CRP-linked risk pathways, metabolic improvements in some studies, and lower dementia/stroke hazards in KIHD extensions—still observational for hard neurologic claims.
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Environmental Health
Microplastics, Inflammation, Oxidative Stress, and Immune Signals
Particles can trigger inflammasome and ROS pathways in models. Human bridges include plaque inflammation and suspected digestive and respiratory harm—still not a complete clinical map.
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Men's Health
Sleep, Inflammation & Allergy Control: Bidirectional Links Without Magic Cures
Short sleep raises inflammatory markers; allergic rhinitis and asthma wreck sleep—optimize both, substitute neither for indicated controllers.
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Environmental Health
Allergy vs Systemic Inflammation: Orthogonal Pathways, Shared Triggers
Type 2 mucosal allergy and sterile systemic residual inflammation are different programs—pollution can touch both without making CRP a hay-fever meter.
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Environmental Health
Air Quality Indoor & Outdoor: PM2.5, Ozone, Allergens & Inflammatory Load
Pollution and indoor hazards drive airway oxidative stress and flares—source control, then ventilation, then filtration.
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Environmental Health
Damp Buildings: Agents Beyond Mycotoxins
Spores, fragments, β-glucans, endotoxins, MVOCs—and moisture chemistry—drive risk mixtures.
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Metabolic Health
IgE Type I Hypersensitivity Explained
Sensitization, FcεRI, mast-cell degranulation—minutes that define classic allergy.
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Metabolic Health
Eczema, Skin Barrier, and the Atopic March
Barrier failure can sensitize through skin; oral exposure may tolerize. March is not destiny.
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Metabolic Health
Allergic Rhinitis and Asthma: United Airways
One airway, shared T2 inflammation—ARIA asks about asthma in every rhinitis patient.
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Nutrition
The Lifestyle Levers That Lower Inflammation (2026)
Lifestyle levers that move inflammatory risk: smoking cessation, visceral fat loss, exercise, sleep, dietary pattern—supplements ranked last with honesty.
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Metabolic Health
hs-CRP and IL-6: Inflammation Markers Without Allergy Confusion
hs-CRP stratifies residual CV inflammatory risk. It does not diagnose food allergy or MCAS.
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Nutrition
Anti-Inflammatory Diet Patterns: What Holds Up Beyond the Label
Mediterranean-class patterns lower inflammatory tone; miracle-food lists usually do not.
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Metabolic Health
Omega-6 to Omega-3 Ratio and Inflammation: What Human Evidence Shows
The ratio is real chemistry. Treating it as a CRP thermometer is not.
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Environmental Health
Microplastics in Blood, Placenta, Plaque, and Brain: What Studies Show
Detection is no longer speculative—Leslie blood, Ragusa placenta, Marfella plaque, and Nihart brain findings—with hard limits on causation.
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Hormones & Genes
Allergens & Inflammation: IgE, Type 2 Pathways, CRP & MCAS Claims
Allergy is not the same as systemic inflammation. Separates IgE from non-IgE disease, maps Type 2 pathways, covers Big 9 foods and LEAP, hs-CRP bands, MCAS triad criteria, and lifestyle adjuncts that do not replace epinephrine.
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