Topic
Hormones And Genes
Hormones And Genes is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
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Hormones & Genes
MTHFR: What to Do and What to Skip (2026)
Do food folate and pregnancy-era folic acid evidence; don't routine SNP panic or detox methylation stacks.
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Hormones & Genes
ACMG MTHFR Guideline: Do Not Routinely Genotype
ACMG 2013 (with later addendum pathway) finds minimal clinical utility for common MTHFR SNPs—do not order for thrombophilia, RPL, or cascade relatives.
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Hormones & Genes
Non-HFE and Juvenile Hemochromatosis: Genes Beyond C282Y
About 10–15% of inherited iron overload is non-HFE (HJV, HAMP, TFR2, SLC40A1). Juvenile forms load fast with early heart and endocrine disease—escalate beyond HFE-only testing.
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Hormones & Genes
HFE C282Y Genetics and Incomplete Penetrance Deep Dive
C282Y/C282Y is common in Northern European ancestry (~1/220–250) but severe end-organ disease is uncommon. Genotype is risk; TSAT/ferritin and organs are expression.
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Hormones & Genes
Fragrance and Endocrine Disruptors: Sex-Axis Synthesis for Men and Women
Women’s higher PCP exposure elevates some phthalate metabolites; male reproductive endpoints and female puberty/reproductive literature both matter.
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Hormones & Genes
MTHFR Variant Frequency by Population: Why “Positive” Is Common
C677T and A1298C alleles are common globally with ancestry differences. Common ≠ rare disease. Frequency should lower panic, not sell protocols.
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Hormones & Genes
MTHFR in Functional Medicine vs ACMG Framing: Two Different Languages
ACMG cautions against routine MTHFR SNP testing for common indications. Functional-medicine marketing often expands SNPs into multi-system narratives. Know which frame you are in.
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Hormones & Genes
MTHFR Myths, Debunked (2026)
Common MTHFR claims ranked by evidence harm—folate, folic acid, SNPs, and when genetics actually change care.
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Hormones & Genes
Severe MTHFR Deficiency vs Common C677T/A1298C SNPs
Two-bucket genetics: rare biallelic disease versus population polymorphisms.
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Hormones & Genes
MTHFR, Thrombophilia, CVD, and Recurrent Pregnancy Loss Myths
Why common MTHFR SNPs are not managed like factor V Leiden—and what HOPE-2 means for hearts.
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Hormones & Genes
Direct-to-Consumer MTHFR Testing: Counseling and Misinterpretation Risks
How raw SNP reports become medical stories—and how to counsel without ACMG violations.
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Hormones & Genes
MTHFR C677T and A1298C: Enzyme Activity vs Clinical Meaning
Teaching residual-activity percentages, thermolabile biology, and why common SNPs are not rare disease.
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Hormones & Genes
Microplastics, Fertility, and Sex Differences: What Evidence Shows
Semen, placenta, and follicular fluid detections raise reproductive questions. Sex-stratify the conversation—unisex fertility panic is not evidence-based communication.
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Hormones & Genes
MTHFR and Nutrition: What to Actually Do (2026)
ACMG-aligned MTHFR actions: skip routine SNP testing hype, use folic acid for NTD prevention, food folate, B12 when deficient, homocysteine context, avoid megadose theater.
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Hormones & Genes
Riboflavin, MTHFR C677T, and Blood Pressure: The Targeted Trial Signal
1.6 mg riboflavin helped 677TT hypertensives in trials—not a cure for “MTHFR disease.”
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Hormones & Genes
Homocysteine, MTHFR, and When the Lab Phenotype Matters
Homocysteine is the actionable phenotype more often than a C677T sticker.
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Hormones & Genes
HFE C282Y Penetrance: Why Genotype Is Not Destiny
C282Y homozygosity raises risk; most homozygotes never get full clinical hemochromatosis.
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Hormones & Genes
Folate vs Folic Acid and MTHFR: What the Evidence Actually Supports
Folic acid prevents neural-tube defects. Methylfolate marketing is not a free rewrite of CDC guidance.
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Hormones & Genes
MTHFR Gene Variants: What Actually Matters Clinically
C677T and A1298C explained with ACMG non-utility, CDC folic acid facts, and riboflavin research graded honestly.
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Hormones & Genes
ACMG MTHFR Testing Guidance: Why Routine SNP Orders Are Discouraged
ACMG: do not order MTHFR polymorphism testing for thrombophilia or recurrent pregnancy loss. Fortification-era evidence dismantled the old causal chain.
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