Topic
Folate
Folate is a recurring research topic on Health Canon. This hub collects related explainers and protocols, newest first, each with evidence grades and practical decision frameworks.
-
Hormones & Genes
MTHFR: What to Do and What to Skip (2026)
Do food folate and pregnancy-era folic acid evidence; don't routine SNP panic or detox methylation stacks.
-
Nutrition
Actionable One-Carbon Nutrition Without MTHFR Genotype
You do not need a SNP to take folic acid for pregnancy, fix B12 deficiency, or eat leafy greens. Grade A actions are phenotype- and life-stage-driven.
-
Hormones & Genes
MTHFR Myths, Debunked (2026)
Common MTHFR claims ranked by evidence harm—folate, folic acid, SNPs, and when genetics actually change care.
-
Nutrition
One-Carbon Nutrition Actions Graded by Evidence
What to do for folate status without an MTHFR test—A through D action list.
-
Women's Health
MTHFR, Pregnancy, and Lactation: Evidence-Based Guidance
Periconception folic acid rules, what changes in pregnancy, and what does not change with SNPs.
-
Women's Health
MTHFR Variants and Neural Tube Defect Risk: Epidemiology
OR ~1.6 for maternal 677TT, folate-modifiable risk, and why intake outranks genotype.
-
Hormones & Genes
MTHFR C677T and A1298C: Enzyme Activity vs Clinical Meaning
Teaching residual-activity percentages, thermolabile biology, and why common SNPs are not rare disease.
-
Nutrition
Methylation Supplement Industry Claims: An Evidence Audit
Pathway diagrams versus outcome trials—what methylation stacks can and cannot claim.
-
Women's Health
Folic Acid for Neural Tube Defect Prevention: Guideline Doses
USPSTF Grade A 400–800 mcg, CDC 400 mcg and 4 mg recurrence rules, and why form matters.
-
Nutrition
Excess Folate and B12 Masking: Risks Beyond MTHFR Marketing
Why high-dose folate without B12 checks can hide hematologic clues while nerves worsen.
-
Metabolic Health
Folate Cycle and One-Carbon Metabolism Explained
How MTHFR, methionine synthase, B12, and SAM connect—without methylation-product theater.
-
Hormones & Genes
MTHFR and Nutrition: What to Actually Do (2026)
ACMG-aligned MTHFR actions: skip routine SNP testing hype, use folic acid for NTD prevention, food folate, B12 when deficient, homocysteine context, avoid megadose theater.
-
Hormones & Genes
Folate vs Folic Acid and MTHFR: What the Evidence Actually Supports
Folic acid prevents neural-tube defects. Methylfolate marketing is not a free rewrite of CDC guidance.
-
Hormones & Genes
MTHFR Gene Variants: What Actually Matters Clinically
C677T and A1298C explained with ACMG non-utility, CDC folic acid facts, and riboflavin research graded honestly.
Frequently asked